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Reviewed April 2008
What is the official name of the TTPA gene?
The official name of this gene is “tocopherol (alpha) transfer protein.”
TTPA is the gene's official symbol. The TTPA gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TTPA gene?
The TTPA gene provides instructions for making the α-tocopherol transfer protein (αTTP), which is found in the liver and brain. This protein controls the distribution of vitamin E obtained from the diet (also called α-tocopherol) to cells and tissues throughout the body. Vitamin E is an antioxidant that protects cells in the body from the damaging effects of unstable molecules called free radicals. Normally, vitamin E derived from food is absorbed in the intestine and then transported into the liver on molecules called chylomicrons. After a meal, chylomicrons are formed to transport fat-soluble vitamins (such as vitamin E), dietary fats, and cholesterol from the intestine to the liver. Once in the liver, αTTP transfers vitamin E from chylomicrons to very low-density lipoproteins (VLDLs), which carry fat, fat-soluble vitamins, and cholesterol from the liver to other tissues throughout the body. The VLDLs are then released into the bloodstream so the accompanying vitamin E can be used in the body. The αTTP protein is also thought to transport vitamin E to nerve cells (neurons) in the brain.
How are changes in the TTPA gene related to health conditions?
Where is the TTPA gene located?
Cytogenetic Location: 8q12.3
Molecular Location on chromosome 8: base pairs 63,059,488 to 63,086,100
The TTPA gene is located on the long (q) arm of chromosome 8 at position 12.3.
More precisely, the TTPA gene is located from base pair 63,059,488 to base pair 63,086,100 on chromosome 8.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TTPA?
You and your healthcare professional may find the following resources about TTPA helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TTPA gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TTPA?
amino acid ; ataxia ; cholesterol ; chylomicrons ; deficiency ; free radicals ; gene ; glutamine ; histidine ; intestine ; low-density lipoproteins ; mutation ; population ; protein ; soluble ; vitamins
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.