|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed March 2014
What is the official name of the TTC37 gene?
The official name of this gene is “tetratricopeptide repeat domain 37.”
TTC37 is the gene's official symbol. The TTC37 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TTC37 gene?
The TTC37 gene provides instructions for making a protein whose function has not been confirmed. Based on its similarity to a protein in other organisms, researchers speculate that the TTC37 protein acts as part of a group of proteins called the SKI complex. This complex is thought to be necessary for the function of another large protein complex known as the cytosolic exosome. Within cells, the cytosolic exosome helps to recognize and break down excess or abnormal messenger RNA (mRNA) molecules. mRNA is a chemical cousin of DNA that serves as the genetic blueprint for protein production. Studies suggest that the cytosolic exosome's role in getting rid of excess and abnormal mRNA is important for cell growth.
Does the TTC37 gene share characteristics with other genes?
The TTC37 gene belongs to a family of genes called TTC (tetratricopeptide (TTC) repeat domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TTC37 gene related to health conditions?
Where is the TTC37 gene located?
Cytogenetic Location: 5q15
Molecular Location on chromosome 5: base pairs 95,463,895 to 95,555,005
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The TTC37 gene is located on the long (q) arm of chromosome 5 at position 15.
More precisely, the TTC37 gene is located from base pair 95,463,895 to base pair 95,555,005 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TTC37?
You and your healthcare professional may find the following resources about TTC37 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TTC37 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TTC37?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.