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The official name of this gene is “tripartite motif containing 37.”
TRIM37 is the gene's official symbol. The TRIM37 gene is also known by other names, listed below.
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication.
The disease is caused by mutations affecting the gene represented in this entry.
|||253250 (http://omim.org/entry/253250)||MULIBREY NANISM|
|605073 (http://omim.org/entry/605073)||TRIPARTITE MOTIF-CONTAINING PROTEIN 37|
Cytogenetic Location: 17q23.2
Molecular Location on chromosome 17: base pairs 57,059,998 to 57,184,265
The TRIM37 gene is located on the long (q) arm of chromosome 17 at position 23.2.
More precisely, the TRIM37 gene is located from base pair 57,059,998 to base pair 57,184,265 on chromosome 17.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You and your healthcare professional may find the following resources about TRIM37 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
autosomal ; autosomal recessive ; centriole ; domain ; gene ; ligase ; motif ; nucleic acid ; protein ; recessive ; syndrome ; transcript ; ubiquitin
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.