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Genetics Home Reference: your guide to understanding genetic conditions
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TRAF1

The information on this page was automatically extracted from online scientific databases.

What is the official name of the TRAF1 gene?

The official name of this gene is “TNF receptor-associated factor 1.”

TRAF1 is the gene's official symbol. The TRAF1 gene is also known by other names, listed below.

What is the normal function of the TRAF1 gene?

From NCBI Gene (http://www.ncbi.nlm.nih.gov/gene/7185):

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

From UniProt (http://www.uniprot.org/uniprot/Q13077):

Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

NOTE: UniProt (http://www.uniprot.org/uniprot/Q13077) suggests using caution when interpreting this information.

How are changes in the TRAF1 gene related to health conditions?

Genetics Home Reference provides information about these conditions associated with changes in the TRAF1 gene:
  • juvenile idiopathic arthritis
  • rheumatoid arthritis
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic

Where is the TRAF1 gene located?

Cytogenetic Location: 9q33-q34

Molecular Location on chromosome 9: base pairs 120,902,392 to 120,929,172

The TRAF1 gene is located on the long (q) arm of chromosome 9 between positions 33 and 34.

The TRAF1 gene is located on the long (q) arm of chromosome 9 between positions 33 and 34.

More precisely, the TRAF1 gene is located from base pair 120,902,392 to base pair 120,929,172 on chromosome 9.

See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.

Where can I find additional information about TRAF1?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the TRAF1 gene or gene products?

  • EBI6
  • MGC:10353

See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What glossary definitions help with understanding TRAF1?

apoptosis ; cell ; domain ; gene ; infection ; isoforms ; ligase ; lymphocyte ; mediate ; molecule ; protein ; receptor ; signal transduction ; transcript ; transduction ; transformation ; ubiquitin ; virus

You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Published: September 15, 2014