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Reviewed September 2015
What is the official name of the TPO gene?
The official name of this gene is “thyroid peroxidase.”
TPO is the gene's official symbol. The TPO gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TPO gene?
The TPO gene provides instructions for making an enzyme called thyroid peroxidase. This enzyme plays a central role in the function of the thyroid gland, a butterfly-shaped tissue in the lower neck. Thyroid peroxidase assists the chemical reaction that adds iodine to a protein called thyroglobulin, a critical step in generating thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).
To function properly, thyroid peroxidase must be located in the cell membrane of certain thyroid cells, called follicular cells. Thyroid peroxidase has several different versions (isoforms), which vary by size and location within the cell. Some versions do not function because they are not located in the cell membrane.
How are changes in the TPO gene related to health conditions?
Where is the TPO gene located?
Cytogenetic Location: 2p25
Molecular Location on chromosome 2: base pairs 1,413,461 to 1,542,727
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The TPO gene is located on the short (p) arm of chromosome 2 at position 25.
More precisely, the TPO gene is located from base pair 1,413,461 to base pair 1,542,727 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TPO?
You and your healthcare professional may find the following resources about TPO helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TPO gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TPO?
autoimmune ; cell ; cell membrane ; congenital ; DNA ; enzyme ; gene ; goiter ; hormone ; hypothyroidism ; iodine ; isoforms ; metabolism ; protein ; synthesis ; thyroglobulin ; thyroid ; thyroid hormones ; tissue
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.