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Reviewed April 2012
What is the official name of the TPM3 gene?
The official name of this gene is “tropomyosin 3.”
TPM3 is the gene's official symbol. The TPM3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TPM3 gene?
The TPM3 gene provides instructions for making a protein called slow muscle alpha (α)-tropomyosin, which is part of the tropomyosin protein family. Tropomyosin proteins regulate the tensing of muscle fibers (muscle contraction) by controlling the binding of two muscle proteins, myosin and actin. In non-muscle cells, tropomyosin proteins play a role in controlling cell shape.
Slow muscle α-tropomyosin is found in skeletal muscles, which are the muscles used for movement. Skeletal muscle is made up of two types of muscle fibers: type I (slow twitch fibers) and type II (fast twitch fibers). Slow muscle α-tropomyosin is found only in type I fibers. Type I fibers are the primary component of skeletal muscles that are resistant to fatigue. For example, muscles involved in posture, such as the neck muscles that hold the head steady, are made predominantly of type I fibers. Slow muscle α-tropomyosin helps regulate muscle contraction in type I skeletal muscle fibers.
How are changes in the TPM3 gene related to health conditions?
Genetics Home Reference provides information about nemaline myopathy, which is also associated with changes in the TPM3 gene.
Where is the TPM3 gene located?
Cytogenetic Location: 1q21.2
Molecular Location on chromosome 1: base pairs 154,155,304 to 154,192,135
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The TPM3 gene is located on the long (q) arm of chromosome 1 at position 21.2.
More precisely, the TPM3 gene is located from base pair 154,155,304 to base pair 154,192,135 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TPM3?
You and your healthcare professional may find the following resources about TPM3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TPM3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TPM3?
acids ; actin ; amino acid ; arginine ; cell ; congenital ; contraction ; cysteine ; gene ; histidine ; muscle cells ; myosin ; protein ; protein sequence ; skeletal muscle ; type I skeletal muscle fibers
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.