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Reviewed August 2014
What is the official name of the TPI1 gene?
The official name of this gene is “triosephosphate isomerase 1.”
TPI1 is the gene's official symbol. The TPI1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TPI1 gene?
The TPI1 gene provides instructions for making an enzyme called triosephosphate isomerase 1. This enzyme is involved in a critical energy-producing process known as glycolysis. During glycolysis, the simple sugar glucose is broken down to produce energy for cells. The triosephosphate isomerase 1 enzyme carries out a specific reaction during glycolysis: the conversion of a molecule called dihydroxyacetone phosphate (DHAP) to glyceraldehyde 3-phosphate. This conversion can go both ways, meaning that the triosephosphate isomerase 1 enzyme can also convert glyceraldehyde 3-phosphate back into DHAP. Additional steps convert glyceraldehyde 3-phosphate into other molecules that ultimately produce energy in the form of a molecule called ATP.
For the triosephosphate isomerase 1 enzyme to be turned on (active), it has to attach (bind) to another triosephosphate isomerase 1 enzyme, forming a two-enzyme complex called a dimer.
How are changes in the TPI1 gene related to health conditions?
Where is the TPI1 gene located?
Cytogenetic Location: 12p13
Molecular Location on chromosome 12: base pairs 6,867,420 to 6,870,946
The TPI1 gene is located on the short (p) arm of chromosome 12 at position 13.
More precisely, the TPI1 gene is located from base pair 6,867,420 to base pair 6,870,946 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TPI1?
You and your healthcare professional may find the following resources about TPI1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TPI1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TPI1?
amino acid ; anemia ; aspartic acid ; ATP ; breakdown ; cardiac ; cell ; cerebellum ; deficiency ; dimer ; enzyme ; gene ; glucose ; glutamic acid ; infection ; molecule ; muscle cells ; mutation ; phosphate ; protein ; simple sugar ; susceptibility ; toxic ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.