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Reviewed June 2011
What is the official name of the TP63 gene?
The official name of this gene is “tumor protein p63.”
TP63 is the gene's official symbol. The TP63 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TP63 gene?
The TP63 gene provides instructions for making a protein called tumor protein p63 (also known simply as p63). The p63 protein functions as a transcription factor, which means it attaches (binds) to certain regions of DNA and controls the activity of particular genes.
The p63 protein interacts with other proteins to turn many different genes on and off at different times. The action of p63 helps regulate numerous cell activities, including cell growth and division (proliferation), cell maintenance, the process by which cells mature to carry out specific functions (differentiation), the ability of cells to stick to one another (cell adhesion), and the orderly self-destruction of cells (apoptosis).
The p63 protein plays a critical role in early development. It is especially important for the normal development of ectodermal structures, such as the skin, hair, teeth, and nails. Studies suggest that it also plays essential roles in the development of the limbs, facial features, urinary system, and other organs and tissues. In addition to its roles in development, the p63 protein appears to be necessary for the maintenance of various cells and tissues later in life.
How are changes in the TP63 gene related to health conditions?
Where is the TP63 gene located?
Cytogenetic Location: 3q28
Molecular Location on chromosome 3: base pairs 189,566,861 to 189,897,279
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The TP63 gene is located on the long (q) arm of chromosome 3 at position 28.
More precisely, the TP63 gene is located from base pair 189,566,861 to base pair 189,897,279 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TP63?
You and your healthcare professional may find the following resources about TP63 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TP63 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TP63?
apoptosis ; carcinoma ; cell ; cell adhesion ; chronic ; cleft palate ; differentiation ; DNA ; domain ; dysplasia ; ectrodactyly ; epidermis ; gene ; malformation ; motif ; palate ; proliferation ; protein ; syndrome ; transcription ; transcription factor ; transformation ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.