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The information on this page was automatically extracted from online scientific databases.

What is the official name of the TOX3 gene?

The official name of this gene is “TOX high mobility group box family member 3.”

TOX3 is the gene's official symbol. The TOX3 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the TOX3 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.

How are changes in the TOX3 gene related to health conditions?

Genetics Home Reference provides information about restless legs syndrome, which is associated with changes in the TOX3 gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the TOX3 gene and its association with health conditions.

Where is the TOX3 gene located?

Cytogenetic Location: 16q12.1

Molecular Location on chromosome 16: base pairs 52,436,424 to 52,547,801

The TOX3 gene is located on the long (q) arm of chromosome 16 at position 12.1.

The TOX3 gene is located on the long (q) arm of chromosome 16 at position 12.1.

More precisely, the TOX3 gene is located from base pair 52,436,424 to base pair 52,547,801 on chromosome 16.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about TOX3?

You and your healthcare professional may find the following resources about TOX3 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the TOX3 gene or gene products?

  • CAGF9
  • TNRC9

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding TOX3?

allele ; cancer ; cell ; chromatin ; DNA ; gene ; glutamine ; isoforms ; Pro ; promoter ; promoter region ; protein ; transcript ; transcription

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: May 4, 2015