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Reviewed May 2006
What is the official name of the TNXB gene?
The official name of this gene is “tenascin XB.”
TNXB is the gene's official symbol. The TNXB gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TNXB gene?
The TNXB gene provides instructions for making a protein called tenascin-X. This protein is found in the space between cells (the extracellular matrix), where it appears to be important for organizing and maintaining the normal structure of tissue that supports the body's muscles, joints, organs, and skin (connective tissue). Specifically, researchers believe that tenascin-X helps determine how collagen fibrils are deposited in the extracellular matrix. This protein may also regulate the structure and stability of elastic fibers. Collagen fibrils and elastic fibers provide support, strength, and flexibility to connective tissue throughout the body.
Does the TNXB gene share characteristics with other genes?
The TNXB gene belongs to a family of genes called fibronectin type III domain containing (fibronectin type III domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TNXB gene related to health conditions?
Where is the TNXB gene located?
Cytogenetic Location: 6p21.3
Molecular Location on chromosome 6: base pairs 32,041,154 to 32,109,373
The TNXB gene is located on the short (p) arm of chromosome 6 at position 21.3.
More precisely, the TNXB gene is located from base pair 32,041,154 to base pair 32,109,373 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TNXB?
You and your healthcare professional may find the following resources about TNXB helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TNXB gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TNXB?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (12 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.