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Reviewed February 2013
What is the official name of the TNNI3 gene?
The official name of this gene is “troponin I type 3 (cardiac).”
TNNI3 is the gene's official symbol. The TNNI3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TNNI3 gene?
The TNNI3 gene provides instructions for making a protein called cardiac troponin I, which is found solely in the heart (cardiac) muscle. Cardiac troponin I is one of three proteins that make up the troponin protein complex in cardiac muscle cells. The troponin complex is associated with a structure called the sarcomere, which is the basic unit of muscle contraction. Sarcomeres are made up of thick and thin filaments. The overlapping thick and thin filaments attach (bind) to each other and release, which allows the filaments to move relative to one another so that muscles can contract. The troponin complex, along with calcium, helps regulate tensing (contraction) of cardiac muscle.
For the heart to beat normally, cardiac muscle must contract and relax in a coordinated way. Cardiac troponin I helps to coordinate contraction of the heart. When calcium levels are low, the troponin complex binds to the thin filament. This binding blocks the interaction between the thick and thin filaments that is needed for muscle contraction. An increase in calcium levels causes structural changes in another troponin complex protein called troponin C, which then triggers the troponin complex to detach from the thin filament, allowing the heart muscle to contract.
How are changes in the TNNI3 gene related to health conditions?
Genetics Home Reference provides information about familial dilated cardiomyopathy, which is also associated with changes in the TNNI3 gene.
Where is the TNNI3 gene located?
Cytogenetic Location: 19q13.4
Molecular Location on chromosome 19: base pairs 55,151,767 to 55,157,732
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The TNNI3 gene is located on the long (q) arm of chromosome 19 at position 13.4.
More precisely, the TNNI3 gene is located from base pair 55,151,767 to base pair 55,157,732 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TNNI3?
You and your healthcare professional may find the following resources about TNNI3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TNNI3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TNNI3?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.