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Reviewed August 2011
What is the official name of the TNFRSF1A gene?
The official name of this gene is “tumor necrosis factor receptor superfamily, member 1A.”
TNFRSF1A is the gene's official symbol. The TNFRSF1A gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TNFRSF1A gene?
The TNFRSF1A gene provides instructions for making a protein called tumor necrosis factor receptor 1 (TNFR1). This protein is found spanning the membrane of cells, with part of the TNFR1 protein outside the cell and part of the protein inside the cell. Outside the cell, the TNFR1 protein attaches (binds) to another protein called tumor necrosis factor (TNF). The interaction of the TNF protein with the TNFR1 protein causes the TNFR1 protein to bind to two other TNFR1 proteins, forming a three-protein complex called a trimer. This trimer formation is necessary for the TNFR1 protein to be functional.
The binding of the TNF and TNFR1 proteins causes the TNFR1 protein to send signals inside the cell. Signaling from the TNFR1 protein can trigger either inflammation or self-destruction of the cell (apoptosis). Signaling within the cell initiates a pathway that turns on a protein called nuclear factor kappa B, which triggers inflammation and leads to the production of immune system proteins called cytokines. Apoptosis is initiated when the TNFR1 protein, bound to the TNF protein, is brought into the cell and starts a process known as the caspase cascade.
Does the TNFRSF1A gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TNFRSF1A gene related to health conditions?
Genetics Home Reference provides information about multiple sclerosis, which is also associated with changes in the TNFRSF1A gene.
Where is the TNFRSF1A gene located?
Cytogenetic Location: 12p13.2
Molecular Location on chromosome 12: base pairs 6,328,756 to 6,342,116
The TNFRSF1A gene is located on the short (p) arm of chromosome 12 at position 13.2.
More precisely, the TNFRSF1A gene is located from base pair 6,328,756 to base pair 6,342,116 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TNFRSF1A?
You and your healthcare professional may find the following resources about TNFRSF1A helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TNFRSF1A gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TNFRSF1A?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.