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The information on this page was automatically extracted from online scientific databases.

What is the official name of the TNFRSF14 gene?

The official name of this gene is “tumor necrosis factor receptor superfamily member 14.”

TNFRSF14 is the gene's official symbol. The TNFRSF14 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the TNFRSF14 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

From UniProt (TNR14_HUMAN)This link leads to a site outside Genetics Home Reference.:

Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.

How are changes in the TNFRSF14 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the TNFRSF14 gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the TNFRSF14 gene and its association with health conditions.

Where is the TNFRSF14 gene located?

Cytogenetic Location: 1p36.32

Molecular Location on chromosome 1: base pairs 2,556,365 to 2,565,622

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBIThis link leads to a site outside Genetics Home Reference.)

The TNFRSF14 gene is located on the short (p) arm of chromosome 1 at position 36.32.

The TNFRSF14 gene is located on the short (p) arm of chromosome 1 at position 36.32.

More precisely, the TNFRSF14 gene is located from base pair 2,556,365 to base pair 2,565,622 on chromosome 1.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about TNFRSF14?

You and your healthcare professional may find the following resources about TNFRSF14 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the TNFRSF14 gene or gene products?

  • ATAR
  • CD270
  • HVEA
  • HVEM
  • TR2

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding TNFRSF14?

alternative splicing ; cell ; gene ; immune response ; infection ; lymphocyte ; mediating ; necrosis ; protein ; receptor ; signal transduction ; splicing ; T-cells ; transcript ; transduction ; tumor ; virus

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: February 1, 2016