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Reviewed July 2014
What is the official name of the TNFRSF13B gene?
The official name of this gene is “tumor necrosis factor receptor superfamily member 13B.”
TNFRSF13B is the gene's official symbol. The TNFRSF13B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TNFRSF13B gene?
The TNFRSF13B gene provides instructions for making a protein called TACI. The TACI protein is found on the surface of immune system cells called B cells. These specialized white blood cells help protect the body against infection from foreign invaders such as bacteria and viruses. When B cells mature, they produce special proteins called antibodies (also known as immunoglobulins). Antibodies attach to specific foreign invaders, marking them for destruction. Through interactions with other proteins, TACI promotes cell signaling, plays a role in B cell survival and maturation, and is involved in the production of antibodies.
Does the TNFRSF13B gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TNFRSF13B gene related to health conditions?
Where is the TNFRSF13B gene located?
Cytogenetic Location: 17p11.2
Molecular Location on chromosome 17: base pairs 16,939,084 to 16,972,088
The TNFRSF13B gene is located on the short (p) arm of chromosome 17 at position 11.2.
More precisely, the TNFRSF13B gene is located from base pair 16,939,084 to base pair 16,972,088 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TNFRSF13B?
You and your healthcare professional may find the following resources about TNFRSF13B helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TNFRSF13B gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TNFRSF13B?
acids ; amino acid ; antibody ; arginine ; autoimmune ; bacteria ; cancer ; cell ; cysteine ; deficiency ; gene ; immune system ; infection ; mutation ; necrosis ; protein ; receptor ; transmembrane ; tumor ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.