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Reviewed February 2010
What is the official name of the TNFRSF11A gene?
The official name of this gene is “tumor necrosis factor receptor superfamily member 11a.”
TNFRSF11A is the gene's official symbol. The TNFRSF11A gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TNFRSF11A gene?
The TNFRSF11A gene provides instructions for making a protein called receptor activator of NF-κB (RANK). This protein plays an important role in bone remodeling, a normal process in which old bone is broken down and new bone is created to replace it. During bone remodeling, RANK helps direct the formation and function of specialized cells called osteoclasts, which break down bone tissue. RANK is located on the surface of immature osteoclasts, where it receives signals that trigger these cells to mature and become fully functional.
Does the TNFRSF11A gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TNFRSF11A gene related to health conditions?
Genetics Home Reference provides information about osteopetrosis, which is also associated with changes in the TNFRSF11A gene.
Where is the TNFRSF11A gene located?
Cytogenetic Location: 18q22.1
Molecular Location on chromosome 18: base pairs 62,325,287 to 62,387,710
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The TNFRSF11A gene is located on the long (q) arm of chromosome 18 at position 22.1.
More precisely, the TNFRSF11A gene is located from base pair 62,325,287 to base pair 62,387,710 on chromosome 18.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TNFRSF11A?
You and your healthcare professional may find the following resources about TNFRSF11A helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TNFRSF11A gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TNFRSF11A?
acids ; autosomal ; autosomal recessive ; bone density ; bone marrow ; bone remodeling ; differentiation ; duplication ; familial ; gene ; immune system ; necrosis ; osteoclast ; protein ; receptor ; recessive ; tissue ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.