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TNFAIP3

TNFAIP3

The information on this page was automatically extracted from online scientific databases.

What is the official name of the TNFAIP3 gene?

The official name of this gene is “tumor necrosis factor, alpha-induced protein 3.”

TNFAIP3 is the gene's official symbol. The TNFAIP3 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the TNFAIP3 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.

How are changes in the TNFAIP3 gene related to health conditions?

Genetics Home Reference provides information about these conditions associated with changes in the TNFAIP3 gene:
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic

Where is the TNFAIP3 gene located?

Cytogenetic Location: 6q23

Molecular Location on chromosome 6: base pairs 137,867,187 to 137,883,313

The TNFAIP3 gene is located on the long (q) arm of chromosome 6 at position 23.

The TNFAIP3 gene is located on the long (q) arm of chromosome 6 at position 23.

More precisely, the TNFAIP3 gene is located from base pair 137,867,187 to base pair 137,883,313 on chromosome 6.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about TNFAIP3?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the TNFAIP3 gene or gene products?

  • A20
  • OTUD7C
  • TNFA1P2

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding TNFAIP3?

apoptosis ; catalytic ; cell ; cytokine ; degradation ; enzyme ; gene ; IFN ; in vitro ; kinase ; ligase ; LPS ; lymphoid ; Lys ; mediating ; necrosis ; phosphorylation ; protein ; receptor ; transcript ; transient ; tumor ; ubiquitin

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 21, 2014