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The official name of this gene is “tumor necrosis factor.”
TNF is the gene's official symbol. The TNF gene is also known by other names, listed below.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
|||600807 (http://omim.org/entry/600807)||ASTHMA, SUSCEPTIBILITY TO|
|||157300 (http://omim.org/entry/157300)||MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1|
|||611162 (http://omim.org/entry/611162)||MALARIA, SUSCEPTIBILITY TO MALARIA, RESISTANCE TO, INCLUDED|
|191160 (http://omim.org/entry/191160)||TUMOR NECROSIS FACTOR|
Cytogenetic Location: 6p21.3
Molecular Location on chromosome 6: base pairs 31,543,343 to 31,546,112
The TNF gene is located on the short (p) arm of chromosome 6 at position 21.3.
More precisely, the TNF gene is located from base pair 31,543,343 to base pair 31,546,112 on chromosome 6.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
apoptosis ; arthritis ; autoimmune ; cachexia ; cancer ; cell ; cell proliferation ; coagulation ; cytokine ; differentiation ; domain ; fever ; gene ; insulin ; insulin resistance ; intracellular ; lipid ; malaria ; metabolism ; migraine ; mutation ; necrosis ; polymorphism ; proliferation ; psoriasis ; secretion ; spectrum ; spondylitis ; susceptibility ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.