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TNF

TNF

The information on this page was automatically extracted from online scientific databases.

What is the official name of the TNF gene?

The official name of this gene is “tumor necrosis factor.”

TNF is the gene's official symbol. The TNF gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the TNF gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

How are changes in the TNF gene related to health conditions?

Genetics Home Reference provides information about these conditions associated with changes in the TNF gene:
NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the TNF gene.
  • Asthma, susceptibility to
  • Migraine
  • Susceptibility to malaria
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the TNF gene and its association with health conditions.
OMIM
Number
Title

Where is the TNF gene located?

Cytogenetic Location: 6p21.3

Molecular Location on chromosome 6: base pairs 31,575,566 to 31,578,335

The TNF gene is located on the short (p) arm of chromosome 6 at position 21.3.

The TNF gene is located on the short (p) arm of chromosome 6 at position 21.3.

More precisely, the TNF gene is located from base pair 31,575,566 to base pair 31,578,335 on chromosome 6.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about TNF?

You and your healthcare professional may find the following resources about TNF helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the TNF gene or gene products?

  • DIF
  • TNFA
  • TNF-alpha
  • TNFSF2

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding TNF?

apoptosis ; arthritis ; autoimmune ; cachexia ; cancer ; cell ; cell proliferation ; coagulation ; cytokine ; differentiation ; domain ; fever ; gene ; insulin ; insulin resistance ; intracellular ; lipid ; malaria ; metabolism ; migraine ; mutation ; necrosis ; polymorphism ; proliferation ; psoriasis ; secretion ; spectrum ; spondylitis ; susceptibility ; tumor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: November 17, 2014