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TMPO

TMPO

The information on this page was automatically extracted from online scientific databases.

What is the official name of the TMPO gene?

The official name of this gene is “thymopoietin.”

TMPO is the gene's official symbol. The TMPO gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the TMPO gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]

From UniProt (LAP2A_HUMAN)This link leads to a site outside Genetics Home Reference.:

May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

From UniProt (LAP2B_HUMAN)This link leads to a site outside Genetics Home Reference.:

May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

How are changes in the TMPO gene related to health conditions?

Genetics Home Reference provides information about familial dilated cardiomyopathy, which is associated with changes in the TMPO gene.
UniProt (LAP2A_HUMAN)This link leads to a site outside Genetics Home Reference. provides the following information about the TMPO gene's known or predicted involvement in human disease.

Cardiomyopathy, dilated 1T (CMD1T): A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.[1]This link leads to a site outside Genetics Home Reference. The disease is caused by mutations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the TMPO gene.
  • Dilated cardiomyopathy 1T[1]This link leads to a site outside Genetics Home Reference.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic
[1]

Where is the TMPO gene located?

Cytogenetic Location: 12q22

Molecular Location on chromosome 12: base pairs 98,515,572 to 98,550,378

The TMPO gene is located on the long (q) arm of chromosome 12 at position 22.

The TMPO gene is located on the long (q) arm of chromosome 12 at position 22.

More precisely, the TMPO gene is located from base pair 98,515,572 to base pair 98,550,378 on chromosome 12.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about TMPO?

You and your healthcare professional may find the following resources about TMPO helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the TMPO gene or gene products?

  • CMD1T
  • LAP2
  • LEMD4
  • PRO0868
  • TP

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding TMPO?

arrhythmia ; cardiomyopathy ; cell ; dilated ; dilation ; DNA ; DNA replication ; gene ; heart failure ; isoforms ; lamin ; nuclear envelope ; nuclear membrane ; nucleus ; protein ; receptor ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: October 20, 2014