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Reviewed October 2011
What is the official name of the TMEM127 gene?
The official name of this gene is “transmembrane protein 127.”
TMEM127 is the gene's official symbol. The TMEM127 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TMEM127 gene?
The TMEM127 gene provides instructions for making a protein that acts as a tumor suppressor protein, which means it prevents cells from growing and dividing too quickly or in an uncontrolled way. The TMEM127 protein controls a signaling pathway that leads to cell growth and survival. Research shows that this pathway, regulated by a protein complex called mTORC1, is blocked (inhibited) by the TMEM127 protein, although the specific action of the TMEM127 protein is unknown.
How are changes in the TMEM127 gene related to health conditions?
Where is the TMEM127 gene located?
Cytogenetic Location: 2q11.2
Molecular Location on chromosome 2: base pairs 96,250,207 to 96,266,012
The TMEM127 gene is located on the long (q) arm of chromosome 2 at position 11.2.
More precisely, the TMEM127 gene is located from base pair 96,250,207 to base pair 96,266,012 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TMEM127?
You and your healthcare professional may find the following resources about TMEM127 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TMEM127 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TMEM127?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.