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The information on this page was automatically extracted from online scientific databases.

What is the official name of the TLE3 gene?

The official name of this gene is “transducin like enhancer of split 3.”

TLE3 is the gene's official symbol. The TLE3 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the TLE3 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

From UniProt (TLE3_HUMAN)This link leads to a site outside Genetics Home Reference.:

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.

How are changes in the TLE3 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the TLE3 gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the TLE3 gene and its association with health conditions.

Where is the TLE3 gene located?

Cytogenetic Location: 15q22

Molecular Location on chromosome 15: base pairs 70,047,790 to 70,097,935

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBIThis link leads to a site outside Genetics Home Reference.)

The TLE3 gene is located on the long (q) arm of chromosome 15 at position 22.

The TLE3 gene is located on the long (q) arm of chromosome 15 at position 22.

More precisely, the TLE3 gene is located from base pair 70,047,790 to base pair 70,097,935 on chromosome 15.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about TLE3?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the TLE3 gene or gene products?

  • ESG
  • ESG3
  • GRG3
  • HsT18976

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding TLE3?

alternate splicing ; carcinoma ; cell ; chemotherapy ; corepressor ; co-repressor ; enhancer ; gene ; ovarian ; protein ; repressor ; splicing ; transcript ; transcription

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: February 8, 2016