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Reviewed September 2013
What is the official name of the TK2 gene?
The official name of this gene is “thymidine kinase 2, mitochondrial.”
TK2 is the gene's official symbol. The TK2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TK2 gene?
The TK2 gene provides instructions for making an enzyme called thymidine kinase 2 that functions within cell structures called mitochondria, which are found in all tissues. Mitochondria are involved in a wide variety of cellular activities, including energy production; chemical signaling; and regulation of cell growth, cell division, and cell death. Mitochondria contain their own genetic material, known as mitochondrial DNA (mtDNA), which is essential for the normal function of these structures. Thymidine kinase 2 is involved in the production and maintenance of mtDNA. Specifically, this enzyme plays a role in recycling mtDNA building blocks (nucleotides) so that errors in mtDNA sequencing can be repaired and new mtDNA molecules can be produced.
How are changes in the TK2 gene related to health conditions?
Where is the TK2 gene located?
Cytogenetic Location: 16q22-q23.1
Molecular Location on chromosome 16: base pairs 66,508,003 to 66,550,412
The TK2 gene is located on the long (q) arm of chromosome 16 between positions 22 and 23.1.
More precisely, the TK2 gene is located from base pair 66,508,003 to base pair 66,550,412 on chromosome 16.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TK2?
You and your healthcare professional may find the following resources about TK2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TK2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TK2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.