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Reviewed September 2014
What is the official name of the THPO gene?
The official name of this gene is “thrombopoietin.”
THPO is the gene's official symbol. The THPO gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the THPO gene?
The THPO gene provides instructions for making a protein called thrombopoietin that promotes the growth and division (proliferation) of cells. This protein attaches to (binds) and turns on (activates) the thrombopoietin receptor, which stimulates several signaling pathways that transmit chemical signals from outside the cell to the cell's nucleus. These pathways are important for controlling the production of blood cells.
Thrombopoietin is especially important for the proliferation of certain blood cells called megakaryocytes, which produce platelets, the cells involved in blood clotting. Research suggests that thrombopoietin signaling may also play a role in the renewal of hematopoietic stem cells, which are stem cells located within the bone marrow that have the potential to develop into red blood cells, white blood cells, and platelets.
Does the THPO gene share characteristics with other genes?
The THPO gene belongs to a family of genes called endogenous ligands (endogenous ligands).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the THPO gene related to health conditions?
Where is the THPO gene located?
Cytogenetic Location: 3q27
Molecular Location on chromosome 3: base pairs 184,371,935 to 184,379,688
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The THPO gene is located on the long (q) arm of chromosome 3 at position 27.
More precisely, the THPO gene is located from base pair 184,371,935 to base pair 184,379,688 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about THPO?
You and your healthcare professional may find the following resources about THPO helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the THPO gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding THPO?
blood clotting ; bone marrow ; cell ; clotting ; colony-stimulating factor ; familial ; gene ; hematopoietic ; inherited ; leukemia ; ligand ; nucleus ; oncogene ; platelets ; proliferation ; protein ; receptor ; stem cells ; thrombosis ; translation ; virus ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.