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Reviewed May 2012
What is the official name of the TH gene?
The official name of this gene is “tyrosine hydroxylase.”
TH is the gene's official symbol. The TH gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TH gene?
The TH gene provides instructions for making the enzyme tyrosine hydroxylase, which is important for normal functioning of the nervous system. Tyrosine hydroxylase takes part in the first step of the pathway that produces a group of hormones called catecholamines. This enzyme helps convert the protein building block (amino acid) tyrosine to a catecholamine called dopamine. Dopamine is also known as a neurotransmitter because it transmits signals between nerve cells in the brain to help control physical movement and emotional behavior. Other catecholamines called norepinephrine and epinephrine are produced from dopamine. Norepinephrine and epinephrine are involved in the autonomic nervous system, which controls involuntary body processes such as the regulation of blood pressure and body temperature.
How are changes in the TH gene related to health conditions?
Where is the TH gene located?
Cytogenetic Location: 11p15.5
Molecular Location on chromosome 11: base pairs 2,163,929 to 2,172,137
The TH gene is located on the short (p) arm of chromosome 11 at position 15.5.
More precisely, the TH gene is located from base pair 2,163,929 to base pair 2,172,137 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TH?
You and your healthcare professional may find the following resources about TH helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TH gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TH?
acids ; allele ; amino acid ; autonomic nervous system ; deficiency ; dopamine ; dystonia ; enzyme ; gene ; hypertension ; involuntary ; nervous system ; neurological ; polymorphism ; protein ; spectrum ; stress ; syndrome ; tyrosine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (15 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.