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Reviewed March 2015
What is the official name of the TGM1 gene?
The official name of this gene is “transglutaminase 1.”
TGM1 is the gene's official symbol. The TGM1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TGM1 gene?
The TGM1 gene provides instructions for making an enzyme called transglutaminase 1. This enzyme is found in cells that make up the outermost layer of the skin (the epidermis). Transglutaminase 1 is involved in the formation of the cornified cell envelope, which is a structure that surrounds skin cells and helps form a protective barrier between the body and its environment. Specifically, transglutaminase 1 forms strong bonds, called cross-links, between the structural proteins that make up the cornified cell envelope. This cross-linking provides strength and stability to the epidermis.
Does the TGM1 gene share characteristics with other genes?
The TGM1 gene belongs to a family of genes called TGM (transglutaminases).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TGM1 gene related to health conditions?
Where is the TGM1 gene located?
Cytogenetic Location: 14q11.2
Molecular Location on chromosome 14: base pairs 24,249,114 to 24,263,210
The TGM1 gene is located on the long (q) arm of chromosome 14 at position 11.2.
More precisely, the TGM1 gene is located from base pair 24,249,114 to base pair 24,263,210 on chromosome 14.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TGM1?
You and your healthcare professional may find the following resources about TGM1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TGM1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TGM1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.