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Reviewed April 2012
What is the official name of the TGFBI gene?
The official name of this gene is “transforming growth factor, beta-induced, 68kDa.”
TGFBI is the gene's official symbol. The TGFBI gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TGFBI gene?
The TGFBI gene provides instructions for making a protein called transforming growth factor beta-induced (TGFBI). This protein is released (secreted) from cells and becomes part of the extracellular matrix, which is an intricate network that forms in the spaces between cells and provides structural support to tissues. The TGFBI protein is thought to play a role in the attachment of cells to one another (cell adhesion) and cell movement (migration). This protein is found in many tissues in the body, including the the clear, outer covering of the eye (the cornea).
How are changes in the TGFBI gene related to health conditions?
Where is the TGFBI gene located?
Cytogenetic Location: 5q31
Molecular Location on chromosome 5: base pairs 136,028,894 to 136,063,817
The TGFBI gene is located on the long (q) arm of chromosome 5 at position 31.
More precisely, the TGFBI gene is located from base pair 136,028,894 to base pair 136,063,817 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TGFBI?
You and your healthcare professional may find the following resources about TGFBI helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TGFBI gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TGFBI?
acids ; amino acid ; amyloid ; arginine ; basement membrane ; cell ; cell adhesion ; collagen ; cornea ; cysteine ; epithelial ; extracellular ; extracellular matrix ; gene ; glutamine ; growth factor ; histidine ; inherited ; lysine ; mutation ; protein ; tissue ; tryptophan
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.