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TFG
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TFG

The information on this page was automatically extracted from online scientific databases.

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What is the official name of the TFG gene?

The official name of this gene is “TRK-fused gene.”

TFG is the gene's official symbol. The TFG gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the TFG gene?

From Entrez GeneThis link leads to a site outside Genetics Home Reference.:

There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

How are changes in the TFG gene related to health conditions?

UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the TFG gene's known or predicted involvement in human disease.

Defects in TFG are a cause of thyroid papillary carcinoma (TPC)[1]This link leads to a site outside Genetics Home Reference.. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.

Entrez GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the TFG gene.
  • Chondrosarcoma, extraskeletal myxoid[2]This link leads to a site outside Genetics Home Reference.
UniProt and Entrez Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number		Main Topic
[1]188550This link leads to a site outside Genetics Home Reference.THYROID CARCINOMA, PAPILLARY
[2]612237This link leads to a site outside Genetics Home Reference.CHONDROSARCOMA, EXTRASKELETAL MYXOID
602498This link leads to a site outside Genetics Home Reference.TRK-FUSED GENE

Where is the TFG gene located?

Cytogenetic Location: 3q12.2

Molecular Location on chromosome 3: base pairs 100,428,133 to 100,467,810

The TFG gene is located on the long (q) arm of chromosome 3 at position 12.2.

The TFG gene is located on the long (q) arm of chromosome 3 at position 12.2.

More precisely, the TFG gene is located from base pair 100,428,133 to base pair 100,467,810 on chromosome 3.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about TFG?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the TFG gene or gene products?

  • FLJ36137
  • TF6
  • TRKT3

See How are genetic conditions and genes named? in the Handbook.

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding TFG?

carcinoma ; cell ; epithelial ; gene ; lymphoma ; malignant neoplasms ; neoplasms ; papillary ; rearrangement ; T3 ; thyroid ; tissue ; transcript ; translocation ; tumor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: May 21, 2012