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Reviewed September 2014
What is the official name of the TET2 gene?
The official name of this gene is “tet methylcytosine dioxygenase 2.”
TET2 is the gene's official symbol. The TET2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TET2 gene?
The TET2 gene provides instructions for making a protein whose function is unknown. Based on the function of similar proteins, researchers believe the TET2 protein is involved in regulating the process of transcription, which is the first step in protein production. Although this protein is found throughout the body, it may play a particularly important role in the production of blood cells from hematopoietic stem cells. These stem cells are located within the bone marrow and have the potential to develop into red blood cells, white blood cells, and platelets. The TET2 protein appears to act as a tumor suppressor, which is a protein that prevents cells from growing and dividing in an uncontrolled way.
How are changes in the TET2 gene related to health conditions?
Where is the TET2 gene located?
Cytogenetic Location: 4q24
Molecular Location on chromosome 4: base pairs 105,145,874 to 105,279,802
The TET2 gene is located on the long (q) arm of chromosome 4 at position 24.
More precisely, the TET2 gene is located from base pair 105,145,874 to base pair 105,279,802 on chromosome 4.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TET2?
You and your healthcare professional may find the following resources about TET2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TET2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TET2?
blood clotting ; bone marrow ; cancer ; cell ; clotting ; fibrosis ; gene ; hematopoietic ; inherited ; leukemia ; myelodysplastic syndrome ; oncogene ; platelets ; protein ; stem cells ; syndrome ; tissue ; transcription ; tumor ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.