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Reviewed May 2011
What is the official name of the TCF4 gene?
The official name of this gene is “transcription factor 4.”
TCF4 is the gene's official symbol. The TCF4 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TCF4 gene?
The TCF4 gene provides instructions for making a gene that attaches (binds) to specific regions of DNA and helps control the activity of many other genes. On the basis of this action, the TCF4 protein is known as a transcription factor. The TCF4 protein is part of a group of proteins known as E-proteins. E-proteins each bind with another identical or similar protein and then bind to a specific sequence of DNA known as an E-box. E-proteins are involved in many aspects of development.
The TCF4 protein is found in the brain, muscles, lungs, and heart. This protein also appears to be active (expressed) in various tissues before birth. The TCF4 protein plays a role in the maturation of cells to carry out specific functions (cell differentiation) and the self-destruction of cells (apoptosis).
Does the TCF4 gene share characteristics with other genes?
The TCF4 gene belongs to a family of genes called bHLH (basic helix-loop-helix).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TCF4 gene related to health conditions?
Genetics Home Reference provides information about Fuchs endothelial dystrophy, which is also associated with changes in the TCF4 gene.
Where is the TCF4 gene located?
Cytogenetic Location: 18q21.1
Molecular Location on chromosome 18: base pairs 55,222,331 to 55,635,993
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The TCF4 gene is located on the long (q) arm of chromosome 18 at position 21.1.
More precisely, the TCF4 gene is located from base pair 55,222,331 to base pair 55,635,993 on chromosome 18.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TCF4?
You and your healthcare professional may find the following resources about TCF4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TCF4 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TCF4?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.