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Reviewed March 2014
What is the official name of the TBXAS1 gene?
The official name of this gene is “thromboxane A synthase 1 (platelet).”
TBXAS1 is the gene's official symbol. The TBXAS1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TBXAS1 gene?
The TBXAS1 gene provides instructions for making an enzyme called thromboxane A synthase 1. This enzyme acts as part of a chemical pathway called the arachidonic acid cascade. Through this multistep pathway, a molecule called arachidonic acid is processed to produce several molecules with diverse functions in the body. As part of this pathway, thromboxane A synthase 1 converts a molecule called prostaglandin H2 into another molecule called thromboxane A2. Thromboxane A2 is involved in normal blood clotting (hemostasis), playing critical roles in the narrowing of blood vessels (vasoconstriction) to slow blood flow and the clumping (aggregation) of blood cell fragments called platelets at the site of an injury.
Studies suggest that the activity of thromboxane A synthase 1 may also be important for bone remodeling, which is a normal process in which old bone is removed and new bone is created to replace it, and for the production of red blood cells in bone marrow.
Does the TBXAS1 gene share characteristics with other genes?
The TBXAS1 gene belongs to a family of genes called CYP (cytochrome P450s).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the TBXAS1 gene related to health conditions?
Where is the TBXAS1 gene located?
Cytogenetic Location: 7q34-q35
Molecular Location on chromosome 7: base pairs 139,778,248 to 140,020,325
The TBXAS1 gene is located on the long (q) arm of chromosome 7 between positions 34 and 35.
More precisely, the TBXAS1 gene is located from base pair 139,778,248 to base pair 140,020,325 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TBXAS1?
You and your healthcare professional may find the following resources about TBXAS1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TBXAS1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TBXAS1?
amino acid ; anemia ; blood clotting ; bone marrow ; bone remodeling ; cell ; clotting ; cytochrome P450 ; dysplasia ; enzyme ; fibrosis ; gene ; hemostasis ; injury ; molecule ; platelets ; prostaglandin ; protein
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.