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Reviewed July 2014
What is the official name of the TAZ gene?
The official name of this gene is “tafazzin.”
TAZ is the gene's official symbol. The TAZ gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the TAZ gene?
The TAZ gene provides instructions for producing a protein called tafazzin. Several different versions (isoforms) of the tafazzin protein are produced from the TAZ gene. Most isoforms are found in all tissues, but some are found only in certain types of cells. Tafazzin is located in structures called mitochondria, which are the energy-producing centers of cells. Tafazzin is involved in altering a fat (lipid) called cardiolipin, which plays critical roles in the mitochondrial inner membrane. Tafazzin adds a fatty acid called linoleic acid to the cardiolipin molecule, which enables cardiolipin to perform its functions. Cardiolipin is necessary for maintaining mitochondrial shape, energy production, and protein transport within cells.
How are changes in the TAZ gene related to health conditions?
Genetics Home Reference provides information about familial dilated cardiomyopathy, which is also associated with changes in the TAZ gene.
Where is the TAZ gene located?
Cytogenetic Location: Xq28
Molecular Location on the X chromosome: base pairs 154,411,517 to 154,421,725
The TAZ gene is located on the long (q) arm of the X chromosome at position 28.
More precisely, the TAZ gene is located from base pair 154,411,517 to base pair 154,421,725 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about TAZ?
You and your healthcare professional may find the following resources about TAZ helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the TAZ gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding TAZ?
cardiomyopathy ; cell ; dilated ; familial ; gene ; heart failure ; immune system ; isoforms ; lipid ; mitochondria ; molecule ; myocardium ; proliferate ; protein ; short stature ; stature ; syndrome ; ventricle ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.