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TACO1

TACO1

The information on this page was automatically extracted from online scientific databases.

What is the official name of the TACO1 gene?

The official name of this gene is “translational activator of mitochondrially encoded cytochrome c oxidase I.”

TACO1 is the gene's official symbol. The TACO1 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the TACO1 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.

How are changes in the TACO1 gene related to health conditions?

Genetics Home Reference provides information about these conditions associated with changes in the TACO1 gene:
UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the TACO1 gene's known or predicted involvement in human disease.

Leigh syndrome (LS): An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. The disease is caused by mutations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the TACO1 gene.
  • Cytochrome-c oxidase deficiency
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the TACO1 gene and its association with health conditions.
OMIM
Number
Title

Where is the TACO1 gene located?

Cytogenetic Location: 17q23.3

Molecular Location on chromosome 17: base pairs 63,600,871 to 63,608,364

The TACO1 gene is located on the long (q) arm of chromosome 17 at position 23.3.

The TACO1 gene is located on the long (q) arm of chromosome 17 at position 23.3.

More precisely, the TACO1 gene is located from base pair 63,600,871 to base pair 63,608,364 on chromosome 17.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about TACO1?

You and your healthcare professional may find the following resources about TACO1 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the TACO1 gene or gene products?

  • CCDC44

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding TACO1?

ataxia ; bilateral ; brainstem ; central nervous system ; cerebellum ; deficiency ; dysphagia ; gene ; hypotonia ; nervous system ; oxidase ; protein ; psychomotor ; syndrome

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: September 1, 2015