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Reviewed January 2012
What is the official name of the T gene?
The official name of this gene is “T, brachyury homolog (mouse).”
T is the gene's official symbol. The T gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the T gene?
The T gene provides instructions for making a protein called brachyury. Brachyury is a member of a protein family called T-box proteins, which play critical roles during embryonic development. T-box proteins regulate the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, T-box proteins are called transcription factors.
The brachyury protein is important for the development of the notochord, which is the precursor of the spinal column in the embryo. The notochord disappears before birth, but in a small percentage of individuals, some of its cells remain in the base of the skull or in the spine. The notochord helps control the development of the neural tube, which is a layer of cells that ultimately develops into the brain and spinal cord.
Does the T gene share characteristics with other genes?
The T gene belongs to a family of genes called TBX (T-boxes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the T gene related to health conditions?
Where is the T gene located?
Cytogenetic Location: 6q27
Molecular Location on chromosome 6: base pairs 166,157,655 to 166,168,668
The T gene is located on the long (q) arm of chromosome 6 at position 27.
More precisely, the T gene is located from base pair 166,157,655 to base pair 166,168,668 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about T?
You and your healthcare professional may find the following resources about T helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the T gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding T?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.