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Reviewed July 2014
What is the official name of the SUMF1 gene?
The official name of this gene is “sulfatase modifying factor 1.”
SUMF1 is the gene's official symbol. The SUMF1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SUMF1 gene?
The SUMF1 gene provides instructions for making an enzyme called formylglycine-generating enzyme (FGE). This enzyme is found in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport. The FGE enzyme modifies other enzymes called sulfatases, which aid in breaking down substances that contain chemical groups known as sulfates. These substances include a variety of sugars, fats, and hormones. Specifically, FGE converts a protein building block (amino acid) within sulfatases called cysteine into a molecule called C-alpha-formylglycine.
How are changes in the SUMF1 gene related to health conditions?
Where is the SUMF1 gene located?
Cytogenetic Location: 3p26.1
Molecular Location on chromosome 3: base pairs 3,782,502 to 4,467,281
The SUMF1 gene is located on the short (p) arm of chromosome 3 at position 26.1.
More precisely, the SUMF1 gene is located from base pair 3,782,502 to base pair 4,467,281 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SUMF1?
You and your healthcare professional may find the following resources about SUMF1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SUMF1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SUMF1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.