|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed September 2011
What is the official name of the STAT4 gene?
The official name of this gene is “signal transducer and activator of transcription 4.”
STAT4 is the gene's official symbol. The STAT4 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the STAT4 gene?
The STAT4 gene provides instructions for a protein that acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. The STAT4 protein is turned on (activated) by immune system proteins called cytokines, which are part of the inflammatory response to fight infection. When activated, the STAT4 protein increases the activity of genes that help immune cells called T-cells mature into specialized T-cells. These specialized T-cells, called Th1 cells, produce specific cytokines and stimulate other immune cells to get rid of foreign invaders (pathogens) in the cell.
Does the STAT4 gene share characteristics with other genes?
The STAT4 gene belongs to a family of genes called SH2 domain containing (SH2 domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the STAT4 gene related to health conditions?
Genetics Home Reference provides additional information about these conditions associated with changes in the STAT4 gene:
Where is the STAT4 gene located?
Cytogenetic Location: 2q32.2-q32.3
Molecular Location on chromosome 2: base pairs 191,029,576 to 191,246,172
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The STAT4 gene is located on the long (q) arm of chromosome 2 between positions 32.2 and 32.3.
More precisely, the STAT4 gene is located from base pair 191,029,576 to base pair 191,246,172 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about STAT4?
You and your healthcare professional may find the following resources about STAT4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the STAT4 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding STAT4?
arthritis ; autoimmune ; autoimmunity ; cell ; DNA ; fibrosis ; gene ; idiopathic ; immune system ; infection ; juvenile ; nucleotide ; protein ; syndrome ; T-cells ; tissue ; transcription ; transcription factor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.