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Reviewed March 2015
What is the official name of the SRY gene?
The official name of this gene is “sex determining region Y.”
SRY is the gene's official symbol. The SRY gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SRY gene?
The SRY gene provides instructions for making a protein called the sex-determining region Y protein. This protein is involved in male sexual development, which is usually determined by the chromosomes an individual has. People usually have 46 chromosomes in each cell. Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics. Girls and women typically have two X chromosomes (46,XX karyotype), while boys and men usually have one X chromosome and one Y chromosome (46,XY karyotype).
The SRY gene is found on the Y chromosome. The sex-determining region Y protein produced from this gene acts as a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. This protein starts processes that cause a fetus to develop male gonads (testes) and prevent the development of female reproductive structures (uterus and fallopian tubes).
How are changes in the SRY gene related to health conditions?
Where is the SRY gene located?
Cytogenetic Location: Yp11.3
Molecular Location on the Y chromosome: base pairs 2,786,855 to 2,787,741
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The SRY gene is located on the short (p) arm of the Y chromosome at position 11.3.
More precisely, the SRY gene is located from base pair 2,786,855 to base pair 2,787,741 on the Y chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SRY?
You and your healthcare professional may find the following resources about SRY helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SRY gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SRY?
cell ; chromosome ; DNA ; dysgenesis ; fetus ; gene ; genitalia ; genitals ; hermaphrodite ; karyotype ; ovarian ; protein ; sex chromosomes ; sex determination ; sperm ; syndrome ; testes ; testis ; tissue ; transcription ; transcription factor ; translocation
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (12 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.