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The information on this page was automatically extracted from online scientific databases.

What is the official name of the SPRED2 gene?

The official name of this gene is “sprouty-related, EVH1 domain containing 2.”

SPRED2 is the gene's official symbol. The SPRED2 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the SPRED2 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

From UniProt (SPRE2_HUMAN)This link leads to a site outside Genetics Home Reference.:

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

How are changes in the SPRED2 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the SPRED2 gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the SPRED2 gene and its association with health conditions.

Where is the SPRED2 gene located?

Cytogenetic Location: 2p14

Molecular Location on chromosome 2: base pairs 65,307,435 to 65,432,637

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBIThis link leads to a site outside Genetics Home Reference.)

The SPRED2 gene is located on the short (p) arm of chromosome 2 at position 14.

The SPRED2 gene is located on the short (p) arm of chromosome 2 at position 14.

More precisely, the SPRED2 gene is located from base pair 65,307,435 to base pair 65,432,637 on chromosome 2.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about SPRED2?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the SPRED2 gene or gene products?

  • Spred-2

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding SPRED2?

growth factor ; kinase ; tyrosine

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: February 8, 2016