|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed March 2011
What is the official name of the SOS1 gene?
The official name of this gene is “SOS Ras/Rac guanine nucleotide exchange factor 1.”
SOS1 is the gene's official symbol. The SOS1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SOS1 gene?
The SOS1 gene provides instructions for making a protein that is involved in pathways within cells that control growth and development. This protein helps control (regulate) the activation of the RAS/MAPK signaling pathway, which helps control several important cell functions. Specifically, it regulates the growth and division of cells (proliferation), the process by which cells mature to carry out specific functions (differentiation), cell movement, and the self-destruction of cells (apoptosis). The SOS1 protein regulates another protein, called Ras, that stimulates cells to grow and divide. This regulation tightly controls the growth of cells and tissues, and is especially important for proper embryonic development.
Does the SOS1 gene share characteristics with other genes?
The SOS1 gene belongs to a family of genes called ARHGEF (Rho guanine nucleotide exchange factors).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the SOS1 gene related to health conditions?
Where is the SOS1 gene located?
Cytogenetic Location: 2p21
Molecular Location on chromosome 2: base pairs 38,981,549 to 39,124,744
The SOS1 gene is located on the short (p) arm of chromosome 2 at position 21.
More precisely, the SOS1 gene is located from base pair 38,981,549 to base pair 39,124,744 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SOS1?
You and your healthcare professional may find the following resources about SOS1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SOS1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SOS1?
acids ; apoptosis ; cell ; cytosine ; differentiation ; DNA ; embryonic ; exon ; gene ; gingiva ; gingival ; guanine ; gums ; hereditary ; mutation ; nucleotide ; proliferation ; protein ; RAS ; syndrome ; tissue
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.