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Genetics Home Reference: your guide to understanding genetic conditions     A service of the U.S. National Library of Medicine®


The information on this page was automatically extracted from online scientific databases.

What is the official name of the SNCAIP gene?

The official name of this gene is “synuclein alpha interacting protein.”

SNCAIP is the gene's official symbol. The SNCAIP gene is also known by other names, listed below.

What is the normal function of the SNCAIP gene?

From NCBI Gene (

This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

From UniProt (SNCAP_HUMAN) (

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.

How are changes in the SNCAIP gene related to health conditions?

NCBI Gene ( lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the SNCAIP gene.
  • Parkinson disease, late-onset (, a catalog designed for genetics professionals and researchers, provides the following information about the SNCAIP gene and its association with health conditions.

Where is the SNCAIP gene located?

Cytogenetic Location: 5q23.2

Molecular Location on chromosome 5: base pairs 122,311,349 to 122,464,099

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBI (

The SNCAIP gene is located on the long (q) arm of chromosome 5 at position 23.2.

The SNCAIP gene is located on the long (q) arm of chromosome 5 at position 23.2.

More precisely, the SNCAIP gene is located from base pair 122,311,349 to base pair 122,464,099 on chromosome 5.

See How do geneticists indicate the location of a gene? ( in the Handbook.

Where can I find additional information about SNCAIP?

You and your healthcare professional may find the following resources about SNCAIP helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the SNCAIP gene or gene products?

  • Sph1
  • SYPH1

See How are genetic conditions and genes named? ( in the Handbook.

What glossary definitions help with understanding SNCAIP?

alternative splicing ; ATP ; atypical ; bradykinesia ; degradation ; dementia ; domain ; etiology ; familial ; family history ; gene ; GTP ; Lewy bodies ; ligase ; motif ; mutation ; protein ; splicing ; sporadic ; substantia nigra ; susceptibility ; tissue ; transcript ; tremor ; ubiquitin

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? ( in the Handbook.

Published: February 1, 2016