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Reviewed November 2008
What is the official name of the SMARCAL1 gene?
The official name of this gene is “SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1.”
SMARCAL1 is the gene's official symbol. The SMARCAL1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SMARCAL1 gene?
The SMARCAL1 gene provides instructions for producing a protein whose specific function is unknown. The SMARCAL1 protein can attach (bind) to chromatin, which is the complex of DNA and protein that packages DNA into chromosomes. Based on the function of similar proteins, the SMARCAL1 protein is thought to influence the activity (expression) of other genes through a process known as chromatin remodeling. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development. When DNA is tightly packed, gene expression is lower than when DNA is loosely packed.
How are changes in the SMARCAL1 gene related to health conditions?
Where is the SMARCAL1 gene located?
Cytogenetic Location: 2q35
Molecular Location on chromosome 2: base pairs 216,412,414 to 216,483,053
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The SMARCAL1 gene is located on the long (q) arm of chromosome 2 at position 35.
More precisely, the SMARCAL1 gene is located from base pair 216,412,414 to base pair 216,483,053 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SMARCAL1?
You and your healthcare professional may find the following resources about SMARCAL1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SMARCAL1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SMARCAL1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.