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The official name of this gene is “solute carrier family 6 (neurotransmitter transporter), member 4.”
SLC6A4 is the gene's official symbol. The SLC6A4 gene is also known by other names, listed below.
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
|607834 (http://omim.org/entry/607834)||ANXIETY HARM AVOIDANCE, INCLUDED|
|164230 (http://omim.org/entry/164230)||OBSESSIVE-COMPULSIVE DISORDER|
|182138 (http://omim.org/entry/182138)||SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, SEROTONIN), MEMBER 4|
Cytogenetic Location: 17q11.2
Molecular Location on chromosome 17: base pairs 30,194,318 to 30,235,967
The SLC6A4 gene is located on the long (q) arm of chromosome 17 at position 11.2.
More precisely, the SLC6A4 gene is located from base pair 30,194,318 to base pair 30,235,967 on chromosome 17.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You and your healthcare professional may find the following resources about SLC6A4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
anxiety ; central nervous system ; depression ; gene ; mediating ; mutation ; nervous system ; obsessive-compulsive disorder ; polymorphism ; presynaptic ; promoter ; protein ; psychomotor ; sodium ; susceptibility ; syndrome ; trauma
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.