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Reviewed June 2011
What is the official name of the SLC25A4 gene?
The official name of this gene is “solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4.”
SLC25A4 is the gene's official symbol. The SLC25A4 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SLC25A4 gene?
The SLC25A4 gene provides the instructions for making a protein called adenine nucleotide translocase type 1 (ANT1). ANT1 functions in mitochondria, which are structures within cells that convert the energy from food into a form that cells can use. This process, called oxidative phosphorylation, converts adenosine diphosphate (ADP) into adenosine triphosphate (ATP), the cell's main energy source. ANT1 forms a channel in the mitochondrion's inner membrane. This channel allows ADP into the mitochondrion and ATP out of the mitochondrion to be used as energy for the cell. ANT1 may also be a part of another structure in the inner membrane called the mitochondrial permeability transition pore. This structure allows various molecules to pass into the mitochondrion and is thought to play a role in the self-destruction (apoptosis) of the cell.
Does the SLC25A4 gene share characteristics with other genes?
The SLC25A4 gene belongs to a family of genes called SLC (solute carriers).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the SLC25A4 gene related to health conditions?
Where is the SLC25A4 gene located?
Cytogenetic Location: 4q35
Molecular Location on chromosome 4: base pairs 185,143,262 to 185,150,383
The SLC25A4 gene is located on the long (q) arm of chromosome 4 at position 35.
More precisely, the SLC25A4 gene is located from base pair 185,143,262 to base pair 185,150,383 on chromosome 4.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SLC25A4?
You and your healthcare professional may find the following resources about SLC25A4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SLC25A4 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SLC25A4?
adenine ; adenosine diphosphate ; adenosine triphosphate ; ADP ; apoptosis ; ATP ; carrier ; cell ; channel ; DNA ; gene ; mitochondria ; nucleotide ; ophthalmoplegia ; oxidative phosphorylation ; permeability ; phosphorylation ; protein ; ptosis ; skeletal muscle ; solute ; tissue
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.