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Reviewed November 2010
What is the official name of the SLC25A20 gene?
The official name of this gene is “solute carrier family 25 (carnitine/acylcarnitine translocase), member 20.”
SLC25A20 is the gene's official symbol. The SLC25A20 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SLC25A20 gene?
The SLC25A20 gene provides instructions for making a protein called carnitine-acylcarnitine translocase (CACT). This protein is essential for fatty acid oxidation, a multistep process that breaks down (metabolizes) fats and converts them into energy. Fatty acid oxidation takes place within mitochondria, which are the energy-producing centers in cells. A group of fats called long-chain fatty acids must be attached to a substance known as carnitine to enter mitochondria. Once these fatty acids are joined with carnitine, the CACT protein transports them into mitochondria. Carnitine is then removed from the long-chain fatty acid and transported back out of mitochondria by the CACT protein. Fatty acids are a major source of energy for the heart and muscles. During periods of fasting, fatty acids are also an important energy source for the liver and other tissues.
Does the SLC25A20 gene share characteristics with other genes?
The SLC25A20 gene belongs to a family of genes called SLC (solute carriers).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the SLC25A20 gene related to health conditions?
Where is the SLC25A20 gene located?
Cytogenetic Location: 3p21.31
Molecular Location on chromosome 3: base pairs 48,856,923 to 48,898,993
The SLC25A20 gene is located on the short (p) arm of chromosome 3 at position 21.31.
More precisely, the SLC25A20 gene is located from base pair 48,856,923 to base pair 48,898,993 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SLC25A20?
You and your healthcare professional may find the following resources about SLC25A20 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SLC25A20 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SLC25A20?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.