|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed June 2006
What is the official name of the SLC25A13 gene?
The official name of this gene is “solute carrier family 25 (aspartate/glutamate carrier), member 13.”
SLC25A13 is the gene's official symbol. The SLC25A13 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SLC25A13 gene?
The SLC25A13 gene provides instructions for making a protein called citrin. This protein is active chiefly in the liver, kidneys, and heart. Within the cells of these organs, citrin is involved in transporting molecules into and out of energy-producing structures called mitochondria. Specifically, citrin carries a protein building block (amino acid) called glutamate into mitochondria and transports the amino acid aspartate out of mitochondria as part of a process called the malate-aspartate shuttle.
An adequate supply of aspartate must be transported out of mitochondria to participate in a process called the urea cycle. The urea cycle is a sequence of chemical reactions that takes place in liver cells. These reactions process excess nitrogen that is generated as the body uses proteins. The excess nitrogen is used to make a compound called urea, which is excreted from the body in urine.
Citrin participates in several other important cellular functions as part of the malate-aspartate shuttle. This protein plays a role in producing and breaking down simple sugars and making proteins. It is also involved in the production of nucleotides, which are the building blocks of DNA and its chemical cousin, RNA.
Does the SLC25A13 gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the SLC25A13 gene related to health conditions?
Where is the SLC25A13 gene located?
Cytogenetic Location: 7q21.3
Molecular Location on chromosome 7: base pairs 96,120,220 to 96,322,147
The SLC25A13 gene is located on the long (q) arm of chromosome 7 at position 21.3.
More precisely, the SLC25A13 gene is located from base pair 96,120,220 to base pair 96,322,147 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SLC25A13?
You and your healthcare professional may find the following resources about SLC25A13 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SLC25A13 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SLC25A13?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.