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SLC11A1

SLC11A1

The information on this page was automatically extracted from online scientific databases.

What is the official name of the SLC11A1 gene?

The official name of this gene is “solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1.”

SLC11A1 is the gene's official symbol. The SLC11A1 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the SLC11A1 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

How are changes in the SLC11A1 gene related to health conditions?

Genetics Home Reference provides information about juvenile idiopathic arthritis, which is associated with changes in the SLC11A1 gene.
NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the SLC11A1 gene.
  • Buruli ulcer, susceptibility to[1]This link leads to a site outside Genetics Home Reference.
  • Mycobacterium tuberculosis, susceptibility to[2]This link leads to a site outside Genetics Home Reference.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic
[1]
[2]

Where is the SLC11A1 gene located?

Cytogenetic Location: 2q35

Molecular Location on chromosome 2: base pairs 218,382,028 to 218,396,893

The SLC11A1 gene is located on the long (q) arm of chromosome 2 at position 35.

The SLC11A1 gene is located on the long (q) arm of chromosome 2 at position 35.

More precisely, the SLC11A1 gene is located from base pair 218,382,028 to base pair 218,396,893 on chromosome 2.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about SLC11A1?

What other names do people use for the SLC11A1 gene or gene products?

  • LSH
  • NRAMP
  • NRAMP1

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding SLC11A1?

arthritis ; carrier ; gene ; infection ; intracellular ; iron ; isoforms ; macrophage ; metabolism ; mycobacterium ; oxygen ; pathogen ; protein ; proton ; reactive oxygen species ; solute ; susceptibility ; synthesis ; tuberculosis ; ulcer

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: August 18, 2014