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Reviewed January 2008
What is the official name of the SIX1 gene?
The official name of this gene is “SIX homeobox 1.”
SIX1 is the gene's official symbol. The SIX1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SIX1 gene?
The SIX1 gene is part of a group of similar genes known as the SIX gene family. Genes in this family provide instructions for making proteins that bind to DNA and control the activity of other genes. Based on this role, SIX proteins are called transcription factors.
The SIX1 protein interacts with several other proteins, including the EYA1 protein, to regulate the activity of genes that are important for normal development. Before birth, these protein interactions appear to be essential for the normal formation of many tissues, including the second branchial arch (a structure that gives rise to tissues in the front and side of the neck), the ears, the kidneys, the nose, an immune system gland called the thymus, and muscles used for movement (skeletal muscles).
Does the SIX1 gene share characteristics with other genes?
The SIX1 gene belongs to a family of genes called homeobox (homeoboxes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the SIX1 gene related to health conditions?
Where is the SIX1 gene located?
Cytogenetic Location: 14q23.1
Molecular Location on chromosome 14: base pairs 60,644,699 to 60,649,437
The SIX1 gene is located on the long (q) arm of chromosome 14 at position 23.1.
More precisely, the SIX1 gene is located from base pair 60,644,699 to base pair 60,649,437 on chromosome 14.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SIX1?
You and your healthcare professional may find the following resources about SIX1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SIX1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SIX1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.