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Reviewed July 2009
What is the official name of the SGCE gene?
The official name of this gene is “sarcoglycan, epsilon.”
SGCE is the gene's official symbol. The SGCE gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SGCE gene?
The SGCE gene provides instructions for making a protein called epsilon (ε)-sarcoglycan, whose function is unknown. The ε-sarcoglycan protein is found within the cell membranes of the lungs, liver, kidneys, and spleen, but it is most abundant in nerve cells (neurons) in the brain and in muscle cells. Researchers suspect that in the brain the ε-sarcoglycan protein plays a role in the functioning of synapses, which are the connections between neurons where cell-to-cell communication occurs.
People inherit one copy of most genes from their mother and one copy from their father. Both copies are typically active, or "turned on," in cells. The SGCE gene, however, is active only when it is inherited from a person's father. This sort of parent-specific difference in gene activation is caused by a phenomenon called genomic imprinting.
How are changes in the SGCE gene related to health conditions?
Where is the SGCE gene located?
Cytogenetic Location: 7q21.3
Molecular Location on chromosome 7: base pairs 94,214,535 to 94,285,520
The SGCE gene is located on the long (q) arm of chromosome 7 at position 21.3.
More precisely, the SGCE gene is located from base pair 94,214,535 to base pair 94,285,520 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SGCE?
You and your healthcare professional may find the following resources about SGCE helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SGCE gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SGCE?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.