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Reviewed April 2009
What is the official name of the SERPINI1 gene?
The official name of this gene is “serpin peptidase inhibitor, clade I (neuroserpin), member 1.”
SERPINI1 is the gene's official symbol. The SERPINI1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SERPINI1 gene?
The SERPINI1 gene provides instructions for making a protein called neuroserpin, which is a type of serine protease inhibitor (serpin). Serpins help control several kinds of chemical reactions by blocking (inhibiting) the activity of certain proteins. Neuroserpin inhibits the activity of an enzyme called tissue plasminogen activator (tPA), which plays a role in cell movement (migration), blood clotting, and inflammation.
As its name suggests, neuroserpin is involved in the development and function of the nervous system. This protein helps control the growth of nerve cells (neurons), particularly specialized extensions called axons that are required for the transmission of nerve impulses. Neuroserpin also plays a role in the development of synapses, which are the connections between neurons where cell-to-cell communication occurs. Synapses can change and adapt over time in response to experience, a characteristic called synaptic plasticity. Neuroserpin helps regulate synaptic plasticity, which suggests that it may be important for learning and memory.
Does the SERPINI1 gene share characteristics with other genes?
The SERPINI1 gene belongs to a family of genes called SERPIN (serine (or cysteine) peptidase inhibitors).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the SERPINI1 gene related to health conditions?
Where is the SERPINI1 gene located?
Cytogenetic Location: 3q26.1
Molecular Location on chromosome 3: base pairs 167,735,643 to 167,825,568
The SERPINI1 gene is located on the long (q) arm of chromosome 3 at position 26.1.
More precisely, the SERPINI1 gene is located from base pair 167,735,643 to base pair 167,825,568 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SERPINI1?
You and your healthcare professional may find the following resources about SERPINI1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SERPINI1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SERPINI1?
acids ; amino acid ; arginine ; axons ; blood clotting ; cell ; clotting ; cysteine ; dementia ; encephalopathy ; enzyme ; epilepsy ; familial ; gene ; glutamic acid ; glycine ; inclusion bodies ; inflammation ; involuntary ; mutation ; myoclonus ; nervous system ; plasticity ; proline ; protease ; protein ; proteinase ; serine ; tissue
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.