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Reviewed July 2009
What is the official name of the SEC23B gene?
The official name of this gene is “Sec23 homolog B, COPII coat complex component.”
SEC23B is the gene's official symbol. The SEC23B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the SEC23B gene?
The SEC23B gene provides instructions for making one component of a large group of interacting proteins called coat protein complex II (COPII). COPII is involved in the formation of vesicles, which are small sac-like structures that transport proteins and other materials within cells. Specifically, COPII triggers the formation of vesicles in a cellular structure called the endoplasmic reticulum (ER), which is involved in protein processing and transport. These COPII vesicles carry proteins that are destined to be exported out of cells (secreted).
The SEC23B protein is very similar to the protein produced from a related gene, SEC23A. These proteins are both components of COPII, and they appear to have overlapping functions. In most types of cells, if one of these proteins is missing, the other may be able to compensate for the loss. However, research indicates that the SEC23B protein may have a unique function in developing red blood cells (erythroblasts).
How are changes in the SEC23B gene related to health conditions?
Where is the SEC23B gene located?
Cytogenetic Location: 20p11.23
Molecular Location on chromosome 20: base pairs 18,507,544 to 18,561,415
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The SEC23B gene is located on the short (p) arm of chromosome 20 at position 11.23.
More precisely, the SEC23B gene is located from base pair 18,507,544 to base pair 18,561,415 on chromosome 20.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about SEC23B?
You and your healthcare professional may find the following resources about SEC23B helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SEC23B gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding SEC23B?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.