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Reviewed January 2008
What is the official name of the RUNX2 gene?
The official name of this gene is “runt-related transcription factor 2.”
RUNX2 is the gene's official symbol. The RUNX2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RUNX2 gene?
The RUNX2 gene provides instructions for making a protein that is involved in bone and cartilage development and maintenance. This protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. Researchers believe that the RUNX2 protein acts as a "master switch," regulating a number of other genes involved in the development of cells that build bones (osteoblasts).
How are changes in the RUNX2 gene related to health conditions?
Where is the RUNX2 gene located?
Cytogenetic Location: 6p21
Molecular Location on chromosome 6: base pairs 45,296,053 to 45,518,818
The RUNX2 gene is located on the short (p) arm of chromosome 6 at position 21.
More precisely, the RUNX2 gene is located from base pair 45,296,053 to base pair 45,518,818 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RUNX2?
You and your healthcare professional may find the following resources about RUNX2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RUNX2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RUNX2?
acute ; acute myeloid leukemia ; amino acid ; cartilage ; cell ; DNA ; domain ; dysplasia ; enhancer ; gene ; leukemia ; myeloid ; osteoblast ; protein ; subunit ; transcription ; transcription factor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.